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KMID : 1123920160300030236
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Korean Journal of Oriental Physiology and Pathology
2016 Volume.30 No. 3 p.236 ~ p.241
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Study of Innate Immunity Suppression of Yeonsan Ogye listed on Dong-eui-bo-gam
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Choi Hak-Joo
Sim Boo-Yong
Joo In-Hwan
Yoo Sun-Kyun
Kim Dong-Hee
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Abstract
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The aim of the study is to evaluate immune-enhancing effects of Yeonsan Ogye. Various extract of Yeonsan Ogye (200 and 400 mg/kg/daily) was treated orally to Balb/c mice for 1 week, before acute inflammation was induced by LPS. After cytokine (IFN-γ, TNF-α, IL-6, and IL-1β) and immune cells (white blood cell, neutrophil, lymphocyte, and monocyte) level by serum and blood were counted. As a result, Oral treatment of Yeonsan Ogye extract to the Balb/c mice were significantly decreased cytokine level in serum, in comparison with control group. in addition, production of white blood cell and monocyte in blood was decreased and granulocyte was increased respectively, in comparison with control. Our results demonstrated that Yeonsan Ogye extracts seem to have significant immune-enhancing. Thus, Yeonsan ogye may be developed as a raw material for new health food and medicine to ease the symptoms related with inflammatory and immune.
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KEYWORD
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Acute inflammation, Cytokine, Immune cells, Suppressrion of innate immunity, Yeonsan Ogye
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